Volume 10 Supplement 1

Abstracts of the 11th Annual SCMR Scientific Sessions - 2008

Open Access

1094 Normal left ventricular structure and function: inflection point in age effects

  • Dipti Gupta1,
  • Sunil T Mathew1,
  • Deepu Alexander1,
  • William Schapiro1,
  • Jing Han1,
  • Michael Passick1,
  • Mark J Goldman1 and
  • Nathaniel Reichek1
Journal of Cardiovascular Magnetic Resonance200810(Suppl 1):A219

DOI: 10.1186/1532-429X-10-S1-A219

Published: 22 October 2008

Background

Existing studies of normal left ventricular (LV) structure and function using contemporary CMR methods (SSFP) are limited either in sample size, age range or verification of normality. Therefore we evaluated LV structure and function in a large, extensively screened cohort over a wide age range.

Methods

Normotensive, non-diabetic, non-obese (BMI < 28) volunteers (n = 218, 119 females), aged 20–89, were screened by 2D echocardiography and CMR was performed using SSFP cine imaging with contiguous 8 mm slices in the LV short axis plane. LV volumes (EDV, ESV), ejection fraction (EF) and mass (M) were determined and indexed (i) to body surface area. (Medis, MASS).

Results

Women had higher EF and lower EDVi, ESVi and LVMi compared to men. With increasing age, systolic blood pressure increased, EDVi and ESVi decreased, EF increased, LVMi did not show a clear trend and LVMi/EDVi increased. However, there was an inflection point at age 50, with EDVi, ESVi and systolic blood pressure for each decade >50 differing significantly from all decades <50 but no differences among decades <50 or >50 years. (Table 1.)

Table 1

Variable

Pooled (n = 218)

Female (n = 119)

Male (n = 99)

 

20–30**

30–40

40–50

50–60

60–70

70+

p

<50 (n = 45)

>= 50 (n = 74)

p

<50 (n = 38)

p

 

LVEDVi

74.7*

77.2

78.2

66.8

66.5

62.8

<.0001

74

63

<.0001

81

<.0001

 

LVESVi

32.9

33.6

32.6

26.6

26.6

24.7

<.0001

30

24

<.0001

37

<.0001

 

LVEF

56.1

56.6

58.6

60.2

59.9

61.1

0.02

60

62

0.04

55

0.002

 

LVMi/EDVi

0.7

0.7

0.7

0.9

0.9

0.8

<.0001

0.7

0.9

<.0001

0.8

<.0001

 

SBP

113

114

114

121

122

126

<.0001

111

121

<.0001

116

0.0001

 

*Mean values **Age in years •Systolic blood pressure

Conclusion

Age and blood pressure related concentric remodeling results in reduced chamber volumes and increased EF in presence of constant LV mass in both men and women. There is an inflection point at age 50 when chamber volumes fall and blood pressure increases in both genders. Further studies are needed to determine the physiologic basis of changes occurring in LV structure and function at age 50.

Authors’ Affiliations

(1)
St. Francis Hospital

Copyright

© Gupta et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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