Volume 10 Supplement 1

Abstracts of the 11thAnnual SCMR Scientific Sessions - 2008

Open Access

2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T

  • Peter Bernhardt1,
  • Axel Bornstedt1,
  • Jochen Spiess1,
  • Vinzenz Hombach1 and
  • Volker Rasche1
Journal of Cardiovascular Magnetic Resonance200810(Suppl 1):A276

DOI: 10.1186/1532-429X-10-S1-A276

Published: 22 October 2008

Background

Blood-oxygen level dependent (BOLD) cardiac magnetic resonance imaging (CMR) is a potential diagnostic tool to differentiate ischemic from non-ischemic myocardium.

Methods

T2* values of the myocardial and calf muscle were measured and compared between 1.5 T and 3 T to quantify the respective changes in the tissue T2* property, its dependency on the spatial resolution and to assess the sensitivity of the different field strength for hypoxia. T2* mapping of the calf muscle was performed in 15 volunteers before, during and after no-flow ischemia of the leg. In 23 healthy volunteers T2* maps of the myocardium were generated. Additionally, T2* was measured during adenosine infusion in eight volunteers.

Results

Mean myocardial T2* at 1.5 T was 47.96 ± 10.69 ms and at 3 T 20.44 ± 4.49 ms. After obstruction of the leg the T2* reduction of the calf at 1.5 T was 3.4% (p = 0.001) and 13.0% at 3 T (p < 0.0001). T2* relaxation increased significantly during adenosine at 1.5 T and 3 T (p < 0.0001).

Conclusion

T2* quantification at 1.5 T and 3 T yields a linear relationship. No significant difference could be observed between breath hold and respiratory navigator gated techniques indicating the feasibility of T2* quantification at high spatial resolution. The T2* decrease during hypoxemia of the calf ant the increase during hyperemia of the myocardium indicate that our presented protocol could possibly be applied for evaluation of inducible myocardial ischemia.

Authors’ Affiliations

(1)
University of Ulm

Copyright

© Bernhardt et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Advertisement