Volume 10 Supplement 1
132 Coronary vessel wall evaluation by MRI in the Multi-Ethnic Study of Atherosclerosis (MESA): physiologic determinants of image quality
© Malayeri et al; licensee BioMed Central Ltd. 2008
Published: 22 October 2008
Coronary artery wall magnetic resonance imaging (MRI) has been developed to assess coronary lumen diameter and wall thickness.
The purpose of this study was to evaluate physiologic parameters that affect measures of coronary wall thickness using black blood MRI pulse sequences.
Imaging was completed in 215/234 (92%) coronary segments; 9 participants had incomplete scans. Mean age was 62.6 ± 8.4 years (45–81 years). Mean body mass index (BMI) was 29.2 ± 5.9 kg/m2. A higher proportion of images with quality of "good" was seen in the RCA (40.5%) compared to the LM and LAD (31.9% and 26.4%, respectively). There was very good agreement between observers in the image quality scores (kappa = 0.79, P < 0.001). Lower heart rate, male gender and longer coronary rest period were associated with higher image quality score (p < 0.05). SNR was higher in participants with Agatston calcium score of more than 10 in the RCA and LM arteries (48.5 vs. 69.7, p = 0.001 & 53.4 vs. 61.6, p = 0.032).
Improved depiction of the coronary artery wall with MRI is related to coronary rest period and atherosclerotic plaque burden as measured by calcium score and inversely related to heart rate. Since longer coronary artery rest periods are associated with improved image quality both for angiography with MRI and coronary artery wall imaging, heart rate lowering methods in association with these techniques appear to be a logical application.
This article is published under license to BioMed Central Ltd.