Volume 10 Supplement 1

Abstracts of the 11th Annual SCMR Scientific Sessions - 2008

Open Access

234 A novel in vivo marker for ischemic tissue injury early after coronary occlusion

  • Hassan Abdel-Aty1,
  • Myra Cocker1,
  • John V Tyberg2 and
  • Matthias G Friedrich1
Journal of Cardiovascular Magnetic Resonance200810(Suppl 1):A95

DOI: 10.1186/1532-429X-10-S1-A95

Published: 22 October 2008

Background

Early identification of acute myocardial ischemia is a diagnostic challenge. We aimed at identifying the earliest time point at which T2-weighted cardiovascular magnetic resonance imaging could visually identify acute ischemia.

Methods

We studied seven dogs with serial T2-weighted and cine imaging at baseline, during and early after transient coronary occlusion (25–35 minutes) in a 1.5 T MRI system. Late gadolinium enhancement was used to assess irreversible injury.

Results

28 ± 4 minutes after experimental coronary artery occlusion, we observed a transmural area of high T2 signal intensity (contrast to noise ratio to remote myocardium 11.0 ± 10; p < 0.0001), matching areas with new onset regional wall motion abnormalities. Late enhancement imaging performed after reperfusion did not show irreversible injury in any of the dogs (Figure 1).

Figure 1

We aimed at identifying the earliest time point at which T2-weighted imaging visually identifies acute ischemia in a dog model(n = 7). T2 imaging detected ischemia 28 ± 4 minutes after coronary occlusion before the onset of irreversible damage as identified by late gadolinium enhancement.

Conclusion

We provide the first preliminary evidence that T2-weighted CMR imaging represents a novel in vivo marker for ischemic tissue injury likely before the onset of irreversible injury. T2-weighted CMR may offer a novel potential means of identifying acute ischemia in acute coronary syndromes.

Authors’ Affiliations

(1)
Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, University of Calgary
(2)
Department of Physiology and Biophysics, University of Calgary, Calgary, Canada

Copyright

© Abdel-Aty et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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