| 2 month | 7 month | 10 month | |||
---|---|---|---|---|---|---|
control (n = 8) | mdx (n = 8) | control (n = 5) | mdx (n = 6) | control (n = 7) | mdx (n = 8) | |
Age, weeks | 8.5 ± 1.3 | 9.2 ± 1.5 | 30.6 ± 1.8 | 33.7 ± 0.7 | 45.2 ± 2.8 | 43.5 ± 1.2 |
Body weight, g | 26.9 ± 1.8 | 23.5 ± 4.1 | 32.2 ± 5.3 | 34.2 ± 1.0 | 30.0 ± 2.9 | 34.5 ± 2.0‡ |
Heart weight, mg | 141 ± 20 | 127 ± 13 | 137 ± 6 | 158 ± 29 | 148 ± 12 | 170 ± 12‡ |
Heart weight/body weight, % | 0.52 ± 0.05 | 0.55 ± 0.13 | 0.43 ± 0.06 | 0.46 ± 0.09 | 0.49 ± 0.03 | 0.49 ± 0.03 |
Heart rate, BPM | 466 ± 42 | 441 ± 40 | 478 ± 38 | 481 ± 54 | 483 ± 29 | 500 ± 22 |
LV diameter, mm | 5.37 ± 0.18 | 5.07 ± 0.35 | 5.43 ± 0.19 | 5.71+ 0.12 | 5.73 ± 0.25 | 5.75 ± 0.08 |
Wall thickness, mm | 0.97 ± 0.16 | 0.81 ± 0.05 | 1.02 ± 0.08 | 1.04 ± 0.09 | 0.94 ± 0.04 | 1.04 ± 0.09* |
Wall thickness/diameter | 0.18 ± 0.03 | 0.16 ± 0.01 | 0.20 ± 0.03 | 0.18 ± 0.02 | 0.17 ± 0.01 | 0.19 ± 0.02 |
LVEDV, μl | 42.8 ± 6.7 | 40.6 ± 7.4 | 42.1 ± 7.4 | 48.2 ± 6.7 | 51.0 ± 7.2 | 47.8 ± 4.2 |
LVESV, μl | 15.3 ± 5.0 | 13.7 ± 3.5 | 18.6 ± 8.4 | 20.9 ± 5.3 | 24.0 ± 6.7 | 24.3 ± 2.9 |
Stroke volume, μl | 27.5 ± 3.1 | 26.9 ± 4.3 | 25.9 ± 0.5 | 27.3 ± 2.3 | 27.0 ± 3.2 | 23.5 ± 3.1 |
Ejection fraction, % | 65 ± 7 | 66 ± 4 | 63 ± 10 | 57 ± 5 | 54 ± 8 | 49 ± 5 |
Cardiac output, ml/min | 12.9 ± 1.5 | 11.8 ± 1.6 | 12.7 ± 0.9 | 13.4 ± 1.3 | 13.0 ± 2.2 | 11.7 ± 1.4 |