Volume 12 Supplement 1

Abstracts of the 13th Annual SCMR Scientific Sessions - 2010

Open Access

Reduction in right ventricular pressure and/or volume overload by percutaneous pulmonary valve implantation improves tricuspid valve function as assessed by MR imaging

  • Philipp Lurz1,
  • Vivek Muthurangu2,
  • Silvia Schievano2,
  • Sachin Khambadkone2,
  • Marina Hughes2,
  • Philipp Bonhoeffer2 and
  • Andrew Taylor2
Journal of Cardiovascular Magnetic Resonance201012(Suppl 1):P4

DOI: 10.1186/1532-429X-12-S1-P4

Published: 21 January 2010

Introduction

Percutaneous pulmonary valve implantation (PPVI) is a less invasive strategy to treat right ventricle (RV) to pulmonary artery (PA) dysfunction. However, in contrast to surgery, concomitant tricuspid valve lesions cannot be treated with this technique.

Purpose

In this study we analysed the incidence of significant tricuspid regurgitation in patients with RV to PA conduit dysfunction and the impact of PPVI on tricuspid valve function

Methods

Magnetic resonance (MR) imaging including biventricular volumes and great vessel blood flow assessment was performed prior to and immediately after PPVI in 137 patients. Retrospectively, out of this patient population, we selected patients who had a tricuspid regurgitation fraction (TRF) > 10% on MR prior to valve implantation. TRF was calculated from right ventricular stroke volume and pulmonary artery forward flow.

Results

A TRF > 10% was seen in 17 patients prior to PPVI (incidence 12.4%). Patients with a TRF > 10% had a significantly higher RV enddiastolic volume than patients with preserved tricuspid valve function (142.7 ± 34.4 vs 108.7 ± 37.0 ml/m2; p < 0.001).

After PPVI, the gradient across the conduit fell from 40.8 ± 12.4 mmHg to 15.9 ± 5.3 mmHg (p < 0.001). In addition, there was a decrease in RV end-diastolic volumes (113.3 ± 20.8 ml/m2 to 89.3 ± 19.6 ml/m2, p < 0.001) and pulmonary regurgitation fraction (16.6 ± 14.6% to 1.9 ± 2.7%, p < 0.024) on MR. Reduction in RV pressure and/or volume overload was associated with a significant reduction in TRF (18.5 ± 6.7% to 8.9 ± 6.7%, p = 0.02).

Conclusion

Significant tricuspid regurgitation in the context of RV to PA conduit dysfunction is not common. Further, relief in RV volume and pressure overload by PPVI improves tricuspid valve function acutely. This is important, when patients are selected for either surgical or percutaneous treatment of RV to PA conduit dysfunction.

Authors’ Affiliations

(1)
UCL Institute of Child Health, London, UK & Heart Centre Leipzig
(2)
UCL Institute of Child Health

Copyright

© Lurz et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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