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Table 2 Univariable Association of Variables with All MACE, All-Cause Mortality, and Non-fatal Events

From: Strong cardiovascular prognostic implication of quantitative left atrial contractile function assessed by cardiac magnetic resonance imaging in patients with chronic hypertension

 

All MACE (N = 48)

All-Cause Mortality (N = 21)

Non-Fatal Events (N = 27)

 

LRχ2

HR (95% CI)

P-value

LRχ2

HR (95% CI)

P-value

LRχ2

HR

P-value

Age (years)

0.41

1.01 (0.99-1.03)

NS

0.51

1.01 (0.98-1.04)

NS

0.02

1.00 (0.97-1.03)

NS

Female Gender

2.12

1.63 (0.84-3.15)

NS

4.65

2.72 (1.10-6.73)

0.03

0.01

1.04 (0.41-2.63)

NS

Body Mass Index (m/kg2)

1.62

0.96 (0.91-1.02)

NS

0.19

0.98 (0.91-1.06)

NS

2.19

0.94 (0.86-1.02)

NS

Hx. Percutaneous Coronary Intervention

3.21

2.07 (0.93-4.56)

0.07

0.54

1.51 (0.51-4.48)

NS

1.97

2.25 (0.73-6.98)

NS

Hx. Coronary Bypass Surgery

3.69

2.25 (0.96-5.13)

0.05

0.23

1.35 (0.40-4.58)

NS

3.44

2.87 (0.94-8.74)

0.06

Diabetes

0.49

1.27 (0.65-2.47)

NS

0.01

1.00 (0.41-2.42)

NS

0.07

1.14 (0.44-2.96)

NS

Hypercholesterolemia

0.10

1.12 (0.54-2.34)

NS

0.82

0.67 (0.28-1.61)

NS

1.53

2.19 (0.63-7.59)

NS

Hx. Heavy Smoking

0.60

1.31 (0.66-2.57)

NS

0.17

0.82 (0.31-2.12)

NS

1.09

1.65 (0.64-4.22)

NS

Family Hx. CAD

1.00

0.66 (0.29-1.49)

NS

0.33

0.77 (0.32-1.85)

NS

0.47

0.67 (0.21-2.11)

NS

Medications

         

   Beta-blocker Use

4.68

2.63 (1.10-6.33)

0.03

4.27

4.65 (1.08-19.96)

0.04

1.08

1.80 (0.59-5.49)

NS

   Calcium Channel Blocker Use

1.08

1.44 (0.72-2.89)

NS

0.01

0.95 (0.35-2.59)

NS

1.66

1.87 (0.72-4.83)

NS

   ACE Inhibitor Use

0.05

0.93 (0.48-1.79)

NS

0.01

0.98 (0.42-2.31)

NS

0.74

0.66 (0.25-1.70)

NS

   Aspirin Use

0.97

1.42 (0.71-2.83)

NS

0.04

0.92 (0.39-2.18)

NS

1.43

1.88 (0.67-5.27)

NS

ECG Variables

         

   History of Atrial Fibrillation on ECG

2.17

2.22 (0.77-6.43)

NS

1.22

2.30 (0.53-10.05)

NS

0.66

1.87 (0.41-8.46)

NS

   Left Atrial Enlargement on ECG

0.01

1.04 (0.36-2.96)

NS

0.62

0.45 (0.06-3.45)

NS

0.61

1.65 (0.47-5.82)

NS

   LVH Voltage and Strain

1.92

1.97 (0.75-5.14)

NS

**

**

NS

7.58

4.43 (1.54-12.77)

<0.01

   Significant Q Waves

0.64

1.53 (0.54-4.39)

NS

3.73

3.00 (0.98-19.12)

0.05

**

**

**

   QRS Interval > 120 ms

0.39

0.72 (0.25-2.04)

NS

0.29

0.67 (0.15-2.91)

NS

0.01

1.08 (0.31-3.77)

NS

   Left Bundle Branch Block

1.21

1.71 (0.66-4.44)

NS

0.05

1.18 (0.27-5.15)

NS

3.31

2.84 (0.92-8.74)

0.07

Right Bundle Branch Block

0.23

0.70 (0.17-2.94)

NS

0.28

1.49 (0.34-6.49)

NS

**

**

**

   Significant ST Changes

1.61

1.72 (0.74-3.98)

NS

0.06

0.83 (0.19-3.62)

NS

3.05

2.55 (0.89-7.32)

0.08

   Significant T Changes

0.03

1.08 (0.47-2.49)

NS

0.10

1.19 (0.39-3.62)

NS

0.07

0.84 (0.24-2.94)

NS

   Prolonged corrected QT Interval

5.15

2.23 (1.12-4.47)

0.02

1.42

1.76 (0.70-4.43)

NS

4.58

2.99 (1.10-8.14)

0.03

CMR Variables of the LV

         

   LVEDD (mm)

0.70

1.02 (0.98-1.06)

NS

2.93

0.95 (0.90-1.01)

0.09

8.32

1.08 (1.02-1.14)

<0.01

   LVEF (per 10%)

2.59

0.84 (0.68-1.04)

NS

0.04

1.03 (0.75-1.42)

NS

5.3

0.71 (0.54-0.95)

0.02

   LVEDVI (per 10 ml/m2)

0.52

1.02 (0.97-1.07)

NS

4.06

0.89 (0.80-1.00)

NS

6.97

1.08 (1.02-1.13)

<0.01

   LVESVI (per 10 ml/m2)

3.66

1.05 (1.00-1.10)

0.06

1.00

0.94 (0.82-1.07)

NS

10.35

1.09 (1.03-1.14)

0.001

   LV Mass (gram)

0.01

1.00 (0.99-1.01)

NS

3.26

0.99 (0.98-1.00)

0.07

1.71

1.00 (1.00-1.01)

NS

   Segmental Wall Motion Abnormality

1.18

1.49 (0.73-3.06)

NS

0.66

1.49 (0.57-3.93)

NS

0.17

1.24 (0.44-3.49)

NS

   Abnormal LV LGE

6.33

2.47 (1.22-5.00)

NS

2.12

2.08 (0.78-5.59)

NS

3.91

2.69 (1.01-7.18)

0.05

CMR Variables of the LA

         

Anteroposterior LA Dimension (mm)

4.64

1.05 (1.00-1.09)

0.03

1.01

1.03 (0.97-1.10)

NS

4.45

1.06 (1.00-1.12)

0.03

LAVmax (ml/m2)

2.50

1.01 (1.00-1.03)

NS

1.60

1.01 (0.99-1.04)

NS

2.94

1.02 (1.00-1.04)

0.09

LAVac (ml/m2)

3.16

1.02 (1.00-1.03)

0.08

2.79

1.02 (1.00-1.04)

0.10

2.99

1.02 (1.00-1.04)

0.08

LAVmin (ml/m2)

6.28

1.02 (1.00-1.03)

0.01

6.48

1.02 (1.00-1.03)

0.01

3.84

1.02 (1.00-1.03)

0.05

LAEFPassive(per 10% reduction)

0.47

1.12 (0.81-1.57)

NS

0.39

1.16 (0.73-1.86)

NS

0.46

1.17 (0.74-1.86)

NS

LAEFContractile(per 10% reduction)

18.84

1.75 (1.36-2.24)

<0.0001

14.17

1.46 (1.20-1.77)

<0.001

6.94

1.35 (1.08-1.70)

<0.01

LAEFTotal (per 10% reduction)

10.91

1.45 (1.16-1.82)

<0.001

10.80

1.38 (1.14-1.68)

0.001

5.05

1.29 (1.03-1.60)

0.02

   Contractile/Passive ratio

10.64

0.94 (0.91-0.98)

<0.001

1.47

0.88 (0.72-1.08)

NS

11.9

0.93 (0.90-0.97)

<0.001

   Contractile/Total Ratio

10.48

0.39 (0.24-0.64)

<0.001

8.75

0.21 (0.08-0.59)

<0.01

1.21

0.48 (0.13-1.77)

NS

  1. * Too Few Events for Analysis
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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