Volume 13 Supplement 1
Arterial spin labeled MRI detects clinically relevant increases in myocardial blood flow with vasodilatation
© Zun et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
This study sought to demonstrate the potential for arterial spin labeling (ASL) to differentiate normal and ischemic myocardial segments based on increase in myocardial blood flow (MBF) with vasodilatation.
Myocardial ASL is a promising technique for the assessment of MBF because of the absence of contrast agents. Patients with end-stage renal disease cannot tolerate contrast agent, and therefore stand to potential benefit from myocardial ASL. MBF in healthy myocardium is known to increase by 4 times during vasodilator-induced stress, compared to at rest .
MBF at rest and during stress (ml/g/min) and perfusion reserve.
Normal whole myocardium
Normal myocardial segments
Ischemic myocardial segments
This study has demonstrated that myocardial ASL is able to capture adenosine-induced MBF increase in normal myocardium while detecting insignificant increase in ischemic myocardium. This suggests that myocardial ASL with vasodilation has a potential to diagnose angiographically significant heart disease.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.