Volume 13 Supplement 1
Combination of compressed sensing and parallel imaging with respiratory motion correction for highly-accelerated cardiac perfusion MRI
© Otazo et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
Cardiac perfusion MRI requires fast data acquisition to achieve an appropriate combination of temporal resolution, spatial resolution and spatial coverage for clinical studies . We have recently presented a combination of compressed sensing and parallel imaging (k-t SPARSE-SENSE) to highly accelerate perfusion studies . However, this method is sensitive to respiratory motion, which decreases temporal sparsity and produces temporal blurring in the reconstructed images. In this work, we present a rigid respiratory motion correction method which allows highly-accelerated first-pass cardiac perfusion MRI to be performed without strict breath-holding.
To develop a respiratory motion correction method for joint compressed sensing and parallel imaging acceleration of first-pass cardiac perfusion MRI.
Free-breathing first-pass cardiac perfusion MRI with 0.1 mmol/kg of Gd-DTPA (Magnevist) was performed using a modified multi-slice TurboFLASH pulse sequence. Healthy volunteers were imaged on a whole-body 3T scanner (Siemens; Tim-Trio) using the standard 12-element body matrix coil array. The relevant imaging parameters include: FOV = 320mmx320mm, image resolution = 1.7mmx1.7mm, slice-thickness = 8mm, TE/TR = 1.3/2.5ms, repetitions=40. An acceleration factor of 8 was used to acquire 10 slices per heartbeat with temporal resolution of 60ms/slice. Data undersampling was performed using a pseudo-random ky-t pattern . Fully-sampled low-resolution coil sensitivity reference data were acquired in the first heartbeat. Image reconstruction was performed in two-steps using the k-t SPARSE-SENSE algorithm  with temporal FFT as sparsifying transform. First, an intermediate k-t SPARSE-SENSE reconstruction is generated for respiratory motion correction. Rigid motion between frames is detected by computing the displacement of each frame from this intermediate k-t SPARSE-SENSE reconstruction with respect to the coil sensitivity reference using a crosscorrelation approach in the image domain . Second, motion correction is performed by aligning all the frames in the accelerated data. The final k-t SPARSE-SENSE reconstruction is computed using the aligned accelerated data.
This work demonstrates feasibility of highly-accelerated first-pass cardiac perfusion MRI without strict breath-holding with rigid respiratory motion correction. Future work will explore the use of non-rigid motion correction. The proposed technique may be useful for imaging patients with impaired breath-hold capabilities.
- Kellman P, et al: J Cardiovasc MR. 2007, 9 (3): 525-537. 10.1080/10976640601187604.Google Scholar
- Otazo , et al: Magn Reson Med. 2010, 64 (3): 767-776. 10.1002/mrm.22463.PubMed CentralView ArticlePubMedGoogle Scholar
- Makela T, et al: IEEE Trans Med Imag. 2002, 21 (9): 1011-1021. 10.1109/TMI.2002.804441.View ArticleGoogle Scholar
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