Volume 13 Supplement 1
Right ventricular strain in patients with tetralogy of Fallot
© Taylor et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
The primary objective was to measure the right ventricular longitudinal strain in a cohort of repaired TOF patients with pulmonary regurgitation using a recently validated feature tracking algorithm.
Left ventricular (LV) circumferential strain shows cardiac dysfunction earlier than ejection fraction. However, measuring right ventricle strain is technically challenging due to the thin RV wall and complex morphology. Also, the predominant RV strain is longitudinal, whereas the predominant LV strain is circumferential. We recently validated a feature tracking algorithm for evaluation of left ventricular strain. Based on that work, we hypothesized that feature tracking would provide accurate and reproducible RV strain metrics for use in longitudinal evaluation of repaired TOF patients.
Forty patients and sixteen normal controls were evaluated. All patients had pulmonary regurgitant fraction > 30% with no residual obstruction. We dichotomized the TOF patients by RVEF (< /= or > 55%) for analysis. CMR image analysis included routine volumetry. Circumferential LV and longitudinal RV strain were calculated using the previously validated feature tracking algorithm. The average strain at the mid-ventricular level was used for comparison. Means were compared using student's t-test and variances were compared with the Lev1:med test.
CMR feature tracking is a validated method for LV strain assessment that can be used reliably for the RV. TOF patients with normal right ventricular function (EF > 55%) have markedly variable strain with increased dispersion in regional strain values. TOF patients with abnormal right ventricular function (EF< 55%) have significantly decreased longitudinal strain and increased strain dispersion. Feature tracking with CMR for strain measurements will be used in a longitudinal evaluation of TOF patients.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.