Volume 13 Supplement 1
Phase contrast mri measurement of e/a and e/e'
© Chatterjee et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
MRI is the accepted gold standard for assessment of left ventricular systolic function; however, no standards are available to assess diastolic function at MRI. E/A and E/e’ ratios are currently used in echocardiography to evaluate left ventricular diastolic function. Measuring these ratios with phase contrast MRI may provide a complementary approach to assessing left ventricular function.
To validate E/A and E/e’ ratios acquired with phase contrast MRI relative to established values using echocardiography.
17 self-reported healthy volunteers were recruited under an IRB approved protocol. Ultra-fast phase contrast data was acquired on a 1.5T Siemens Aera using both breath-hold (30 frames per cardiac cycle) and free breathing (50 frames per cardiac cycle) paradigms. To measure e’ velocities, phase contrast data (Venc 25cm/s) was acquired in the short axis orientation at a slice position where the myocardium on the apical side of the valve ring was within the slice throughout the cardiac cycle. To measure E and A velocities, phase contrast data (Venc 80 cm/s) was acquired in a single slice parallel to the mitral valve annulus, positioned such that the slice stayed below the valve throughout the entire cardiac cycle. E and A velocities as well as septal and lateral e’ velocities were calculated using standard flow post-processing. 2 subjects were excluded from both analyses due to improper gating, and 4 additional subjects were excluded from the breath hold analysis due to too much noise to identify e’ velocities.
With free breathing, E/A was measured at 1.7 ± 0.5 (range 0.8 - 2.6), septum E/e’ was measured at 5.4 ± 1.5 (range 2.5 - 7.4), and lateral E/e’ was measured at 5.1 ± 1.7 (range 2.6 - 8.4). With breath hold, E/A was measured at 1.5 ± 0.6 (range 0.7 - 2.7), septum E/e’ was measured at 6.1 ± 2.2 (range 3.6 - 10.2), and lateral E/e’ was measured at 5.4 ± 2.1 (range 3.5 - 10.9). Subjects with E/e’ above 8.0 had normal left atrial size.
Measured E/A and E/e’ values are within normal limits using cutoff values that have been published with echocardiography , suggesting that phase contrast MRI may provide a complementary approach to assessing left ventricular diastolic function.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.