Volume 14 Supplement 1
Comparison of local sine wave modelling with harmonic phase analysis for the assessment of circumferential myocardial strain from tagged cardiovascular magnetic resonance images
© Miller et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
Assessment of regional ventricular deformation is more sensitive than ejection fraction (EF) for detecting myocardial dysfunction. We sought to compare a local sine-wave modelling (SinMod) method with the more established harmonic phase analysis (HARP) technique, for assessment of Lagrangian left ventricular (LV) peak systolic circumferential strain (εcc) from tagged cardiovascular magnetic resonance images, in patients with cardiomyopathies and healthy volunteers. The variability and rapidity of each technique, and the effect of contrast, were also assessed.
Sixty participants (15 each with hypertrophic, dilated or ischaemic cardiomyopathy and 15 healthy controls) with a wide range of LV ejection fraction (14-78%) underwent spatial modulation of magnetization tagging of a mid-ventricular short-axis slice at 1.5 Tesla. Global and segmental peak transmural εcc were measured using HARP and SinMod. Repeated measurements were performed on 15 randomly selected scans (25%) in order to assess observer variability. Tagged images were acquired pre- and post-contrast in 10 additional patients in order to assess the effect of contrast.
SinMod and HARP-based measurements of global εcc have a high level of agreement. Agreement is substantially lower for measurement of segmental εcc. The SinMod method has generally lower observer variability, is faster and is less affected by contrast.
Dr Miller was supported by a Doctoral Research Fellowship from the National Institute for Health Research, UK (NIHR-DRF-2010-03-98). Dr Schmitt was supported by Greater Manchester Comprehensive Local Research Network funding. Dr McCann and Dr Steadman received support from the NIHR Leicester Cardiovascular Biomedical Research Unit and additionally, Dr Steadman was funded by the British Heart Foundation (PG/07/068/2334).
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.