Table 1 Comparison of clinical TTE and CMR data
Healthy subjects | AS patients | |
|---|---|---|
(n=8, mean±SD) | (n=60, mean±SD) | |
Patient demographics | ||
Age (years) | 34 ± 8 | 64 ± 15 * |
Gender (men %) | 75 | 65 |
Body surface area (m2) | 1.93 ± 0.26 | 1.82 ± 0.19 |
Systolic arterial pressure (mmHg) | 116 ± 10 | 132 ± 23 |
Diastolic arterial pressure (mmHg) | 77 ± 5 | 72 ± 12 |
Doppler echocardiography data | ||
Valve phenotype (bicuspid, %) | 36 | |
Aortic valve hemodynamics | ||
Stroke volume (mL) | 80 ± 20 | 80 ± 13 |
Mean transvalvular gradient (mmHg) | 5 ± 1 | 20 ± 10 * |
Valve effective orifice area (cm2) | 2.67 ± 0.47 | 1.19 ± 0.28 * |
Systemic arterial hemodynamics | ||
Systemic arterial compliance (mL.m-2.mmHg-1) | 1.06 ± 0.21 | 0.91 ± 0.32 |
Systemic vascular resistance (dyne.s.cm-5) | 1448 ± 319 | 1515 ± 338 |
Cardiovascular magnetic resonance data | ||
Aortic valve hemodynamics | ||
Stroke volume (mL) | 84 ± 14 | 76 ± 17 |
Mean transvalvular gradient (mmHg) | 3 ± 1 | 12 ± 7 * |
Valve effective orifice area (cm2) | 3.08 ± 0.8 | 1.4 ± 0.41 * |
Energy loss (mmHg) | 3.33 ± 1.11 | 13.81 ± 7.99 * |
Mean systolic vorticity (1/s) | 88 ± 13 | 125 ± 35 * |
Strouhal | 0.0174 ± 0.0034 | 0.0087 ± 0.0029 * |