- Moderated poster presentation
- Open access
- Published:
Evolution of aortic wall thickness: long-term follow up from the Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of Cardiovascular Magnetic Resonance volume 15, Article number: M14 (2013)
Background
A number of studies have been published over the years concerning the relationship between the thickened intima of human arteries and atherogenesis. Increased arterial wall thickness is associated with the prevalence and incidence of cardiovascular disease. Age-related increases of aortic wall thickness have been reported in several cross-sectional community-based studies. However, longitudinal changes of these measurements have not yet been documented. The purpose of this study is to characterize age- and sex-specific aortic wall thickness (AWT) distributions and yearly rates of change in older adults.
Methods
371 longitudinal and 426 cross sectional studies with AWT images by MRI were analyzed. MRI was performed at first in MESA1 (baseline, 2000-2001), and then in MESA5 (ten-year follow-up, 2010-2011). Both exams used 1.5-T whole-body MRI systems. Images were obtained using a double inversion recovery black-blood fast spin-echo sequence with ECG gating. Axial images of the descending thoracic aorta were obtained at the level of the right pulmonary artery. The thickness of the midthoracic descending aortic wall was measured using electronic calipers at 4 standard positions: 12, 3, 6, and 9 o'clock (QMASS 7.2). The average value of these 4 measurements was calculated.
Results
Table 1 lists demographics and AWT in MESA5 (2010-2011), and changes of AWT in ten years stratified by gender. AWT and cardiac function were significantly different between men and women. Changes of AWT were greater for men than women, but not significant. The average yearly rate of AWT change was 0.032mm. Figure 1 displays the average AWT increase in ten years by age categories (in the baseline age). AWT increased more markedly in mid-adulthood, and was plateaued over time into late-adulthood (p-trend < 0.001). Framingham global CVD risk score assessed at the baseline was positively correlated with the AWT measured in MESA5 (R=0.261, p < 0.001).
Conclusions
We report aortic wall thickness changes over mid to late adulthood in longitudinal comparisons. Further analyses will reveal the correlates of these alterations with clinical variables.
Funding
N01-HC-95168 from the National Heart, Lung, and Blood Institute
Author information
Authors and Affiliations
Rights and permissions
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Liu, CY., Chen, D., Teixido-Tura, G. et al. Evolution of aortic wall thickness: long-term follow up from the Multi-Ethnic Study of Atherosclerosis (MESA). J Cardiovasc Magn Reson 15 (Suppl 1), M14 (2013). https://doi.org/10.1186/1532-429X-15-S1-M14
Published:
DOI: https://doi.org/10.1186/1532-429X-15-S1-M14