Chronic Obstructive Pulmonary Disease (COPD) is associated with pulmonary artery stiffness - the MESA COPD study

Table 2 Mean difference (in %) and predicted mean levels (in %) of distensibility in the MESA COPD Study by COPD severity.

	Controls n=155	Mild n=54	Moderate n=65	Severe n=16	P-Trend
Distensibility of main PA
Model 1, mean difference	Reference	-1.49	-1.44	-2.78	0.04
Model 1, predicted mean	15.41	13.91	13.97	12.67
Model 2, mean difference	Reference	-1.48	-1.44	-2.56	0.08
Model 2, predicted mean	15.40	13.93	12.49	9.94
	n=143	n=50	n=62	n=14
Distensibility of right PA
Model 1, mean difference	Reference	-0.58	-3.30*	-3.83	0.005
Model 1, predicted mean	20.59	20.01	16.71	12.88
Model 2, mean difference	Reference	-0.93	-3.62*	-3.85	0.01
Model 2, predicted mean	20.67	19.74	16.12	12.27
Distensibility of left PA
Model 1, mean difference	Reference	-4.17*	-3.34*	-4.08	0.002
Model 1, predicted mean	18.26	14.08	10.74	6.67
Model 2, mean difference	Reference	-4.63*	-3.33*	-2.66	0.003
Model 2, predicted mean	18.25	13.62	10.29	7.64

*p < 0.05 Model 1 adjusted for age, race, gender, height, weight, and cohort Model 2 adjusted for variables in model 2 in addition to smoking status, pack years, educational attainment, diabetes mellitus, hypertension, oxygen saturation, LDL, HDL and statin use.

ISSN: 1532-429X