Volume 15 Supplement 1
Novel highly accelerated real-time CINE-MRI featuring compressed sensing with k-t regularization in comparison to TSENSE segmented and real-time Cine imaging
© Schmidt et al; licensee BioMed Central Ltd. 2013
Published: 30 January 2013
In patients with breath-holding difficulties or arrhythmia, real-time CINE-MRI is preferred over segmented acquisitions in one breath-hold. However, common real-time sequences require a deteriorating trade-off between spatial and temporal resolution. In the current work, highly accelerated real-time CINE-MRI which features compressed sensing with k t regularization  was evaluated against segmented and real-time imaging with TSENSE in healthy volunteers as a potential alternative providing both high spatial and temporal resolution in real time.
Sparse and incoherent sampling was implemented in a bSSFP 2D CINE-MRI sequence and a compressed sensing image reconstruction program featuring k-t regularization was provided. Thirteen healthy volunteers (7m/6f, age 43±17y, BMI 24±6.6) underwent CMR imaging on a 1.5T system (MAGNETOM Aera, Siemens AG, Erlangen, Germany). 2-/3-/4-chamber as well as 3 short-axis views were acquired with a fixed temporal resolution of 33 ms but different net acceleration factors (NAF) and acquisition durations (acq) based on the used sequences:
(1) segmented TSENSE, NAF 2, (sTSENSE2), acq: 6 heartbeats
(2) segmented TSENSE, NAF 4, (sTSENSE4), acq: 3 heartbeats
(3) real-time TSENSE, NAF 4, (rtTSENSE4), acq: 1 heartbeat
(4) real-time compressed sensing, NAF 10.9, (rtCS11), acq: 1 heartbeat
Spatial Resolution/SLT (mm)
Mean overall image quality
Comparison with rtCS11
As the image quality of rtCS11 was significantly better than in case of real-time TSENSE and close to that of sTSENSE4, the novel method may become a better alternative for the assessment of cardiac function in real time. Further studies in a clinical setting are required to assess the performance in challenging cases.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.