Figure 1

A) Simulated arterial input and tissue contrast agent concentration (based on 5 ml/s bolus injection and 1 ml/g/min perfusion). B) In-vivo blood (LV pool) and myocardial signal (normalized to baseline) for a bolus injection (XX ml at 5 ml/s) in a healthy control. C) Myocardial tissue response for an idealized step-input for 1 ml/g/min perfusion. D) In-vivo blood (LV pool) and myocardial signal (normalized to baseline) for an optimized pseudo-step-input protocol (same subject as B).