Volume 18 Supplement 1
In vivo cardiac DTI on a widely available 3T clinical scanner: an optimized M2 approach
© Nguyen et al. 2016
Published: 27 January 2016
Currently, there are only two main methods to perform diffusion tensor CMR (DT-CMR) that either rely on the subject exhibiting stable, periodic RR cycle (stimulated echo ) or utilize specialized research scanners that have ultra-high gradient strengths (spin-echo ). Recent work has demonstrated that gradient moment nulling (GMN) of the second order is capable of yielding robust diffusion weighted images (DWI) . To extend this work, we present a novel DT-CMR sequence prototype that utilizes a M2 GMN gradient scheme that is robust to imperfect B1 refocusing at high main fields (≥3T). We compare this with no GMN compensation (M0) and first order GMN compensation (M1). Patients with advanced heart failure (HF) were also scanned to test its ability in a clinical setting.
Twenty healthy subjects and two HF patients were recruited and consented under Institutional Review Board. All subjects were scanned on a 3T Siemens (MAGNETOM Verio, Siemens Healthcare GmbH, Erlangen) with the following protocol: standard morphological localizers and 3 DTI scans (b30 + 6 directions b = 300 s/mm2, free breathing prospective navigator gating, bSSFP readout, 2.7 × 2.7 × 8 mm3, flip angle = 90°, single-shot + MoCo) utilizing M0 (TEprep = 35 ms), M1 (TEprep = 46 ms), and M2 (TEprep = 67 ms). Acquisition was carried out during the quiescent period of diastole. Gradient amplitudes were set to 60.8 mT/m (two 43 mT/m max gradients simultaneously on). DTI reconstruction utilized custom software developed in Python using the DIPY library  to generate mean diffusivity (MD), fractional anisotropy (FA), and helix angle (HA) maps. Success rates defined by >90% of the myocardium unaffected by motion was reported. Paired t-tests were utilized to statistically test for significance (p < 0.05).
For mildly low heart rates (HR) (< 75 beats-per-min) in volunteers, M2 was shown to have significantly (p < 0.05) higher success rates (93%) than M1 (62%) and M0 (28%). For higher HR, M2 was still significantly (p < 0.05) higher success rates (57%) than M1 (23%) and M0 (7%), but much notably lower success than at lower HR. Among the scans with minimal motion artifacts, MD and FA were significantly (p < 0.05) lower for M2 (1.3 ± 0.2 μm2/ms, 0.3 ± 0.2) than M0 (4.8 ± 1.3 μm2/ms, 0.8 ± 0.6) and M1 (1.8 ± 0.2 μm2/ms, 0.3 ± 0.2) with M2 values being consistent with previous literature [1, 2]. In HF patients (HR = 80 and 83), M2 alone was only capable of yielding motion-artifact free MD, FA, and HA maps.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.