Table 2 Indication for treatment

B

Grade 1R

Tacrolimus goal increased

Histological: Persistent 1R biopsy × 3

B

Grade 1R

Tacrolimus goal increased

Hemodynamics: systolic dysfunction (mildly decreased left ventricular function)

B

Grade 0

Low dose steroids

Hemodynamics: diastolic dysfunction (elevated right end diastolic pressure and capillary wedge pressure); new positive DSA

B

Grade 1R

Tacrolimus goal increased

Hemodynamics: systolic dysfunction (mildly decreased left ventricular function)

B

Grade 1R

Tacrolimus goal increased

Hemodynamics: diastolic dysfunction (elevated pulmonary wedge pressures)

B

Grade 1R

Oral steroids (not pulse dose)

Hemodynamics: diastolic dysfunction (elevated right end diastolic pressure and pulmonary capillary wedge pressure)

B

Grade 0

MMF dose increased

Hemodynamics: systolic dysfunction (mildly decreased biventricular function)

C

Grade 1R

Oral pulse steroids

Hemodynamics: diastolic dysfunction (elevated right end diastolic pressures and capillary wedge pressure)

C

Grade 1R

IVIG and rituximab

Hemodynamics: systolic dysfunction (decreased biventricular function, requiring milrinone)

C

Grade 1R

IV pulse steroids

Hemodynamics: diastolic dysfunction (elevated right end diastolic pressures and pulmonary capillary wedge pressure) and decreased cardiac index (requiring epinephrine)

C

Grade 1R

IV pulse steroids, IVIG, rituximab

Hemodynamics: diastolic dysfunction (elevated right end diastolic pressure and capillary wedge pressure); Worsening DSA

C

Grade 2R

IV pulse steroids, thymoglobulin

Histological and hemodynamics: diastolic dysfunction (elevated right end diastolic pressures and right atrial pressure)

C

Grade 2R

IV pulse steroids, thymoglobulin

Histological