Table 4 Clinical measures by thoracic duct tortuosity in patients with Fontan circulation (N = 169)
Variable | None/mild (n = 119) | Moderate /severe (n = 50) | p-value | ||
|---|---|---|---|---|---|
n | Value | n | Value | ||
CMR | |||||
EDV/BSA, ml/m2 | 86 | 116 ± 33.9 | 35 | 132.3 ± 45.7 | 0.06 |
ESV/BSA, ml/m2 | 84 | 57.3 ± 26.0 | 32 | 70.0 ± 29.9 | 0.03 |
Mass/BSA, g/m2 | 77 | 64.5 ± 22.7 | 28 | 75.6 ± 37.0 | 0.15 |
EF, % | 84 | 52.4 ± 8.6 | 32 | 49.2 ± 8.4 | 0.09 |
APC, % | 20 | 16.8 ± 9.6 | 8 | 21.0 ± 9.5 | 0.31 |
Moderate or worse AVVR (echo) | 85 | 9 (11%) | 39 | 7 (18%) | 0.26 |
Cath | |||||
Mean Fontan pressure, mmHg | 27 | 15.0 ± 3.0 | 18 | 16.5 ± 3.6 | 0.14 |
PVR, WUm2 | 26 | 2.16 ± 0.77 | 17 | 1.72 ± 0.83 | 0.09 |
Max EDP, mmHg | 26 | 8.96 ± 2.60 | 17 | 10.53 ± 2.65 | 0.06 |
CPET | |||||
Peak RER | 34 | 1.20 ± 0.09 | 11 | 1.18 ± 0.09 | 0.42 |
Peak VO2, mL × kg−1 × min−1 | 34 | 24.1 ± 7.2 | 11 | 20.8 ± 7.2 | 0.19 |
% predicted VO2 max | 34 | 62.4 ± 14.0 | 11 | 58.6 ± 16.0 | 0.46 |
% predicted peak O2 pulse | 34 | 76.5 ± 20.9 | 11 | 72.0 ± 22.1 | 0.54 |
% predicted peak work rate | 33 | 71.5 ± 17.8 | 11 | 65.2 ± 23.3 | 0.35 |
Relative VO2 at VAT mL × kg−1 × min−1 | 34 | 14.3 ± 3.9 | 11 | 13.7 ± 4.5 | 0.69 |
%VAT/Predicted peak VO2 | 34 | 37.3 ± 7.9 | 11 | 39.3 ± 12.6 | 0.63 |
VE/VCO2 slope | 34 | 35.4 ± 7.5 | 11 | 30.9 ± 7.4 | 0.09 |
LAB | |||||
Creatinine, mg/dL | 52 | 0.70 ± 0.20 | 35 | 0.61 ± 0.22 | 0.04 |
Albumin, mg/dL | 49 | 4.4 ± 0.6 | 33 | 4.4 ± 0.5 | 0.71 |
Absolute Lymphocyte Count, K cells/µL | 13 | 0.76 ± 0.36 | 9 | 1.80 ± 0.78 | 0.003 |