Patients with HFrEF (n = 40) | Patients with HFmrEF (n = 8) | Patients with HFpEF (n = 22) | Healthy controls (n = 35) | |
---|---|---|---|---|
Demographics | ||||
Females (%) | 11 (28) | 0 (0) | 7 (32) | 14 (40) |
Age (years ± SD) | 63 ± 13 | 59 ± 11 | 56 ± 17 | 55 ± 11 |
BMI (kg/m2 ± SD) | 27.0 ± 6.0 | 23.3 ± 2.5 | 29.7 ± 5.2 | 24.6 ± 4.7 |
BSA (m2 ± SD) | 1.94 ± 0.27 | 1.89 ± 0.18 | 2.03 ± 0.18 | 1.89 ± 0.24 |
Active smokers (%) | 8 (20) | 2 (25) | 4 (18) | 0 (0) |
BNP (pg/ml) | 924 ± 2412a | 871 ± 1233a | 142 ± 174a | n/a |
NYHA class | ||||
I (%) | 11 (28) | 2 (25) | 8 (36) | n/a |
II (%) | 11 (28) | 5 (63) | 9 (41) | n/a |
III (%) | 17 (42) | 1 (12) | 4 (18) | n/a |
IV (%) | 1 (2) | 0 (0) | 1 (5) | n/a |
Aetiology of HF | ||||
DCM (%) | 19 (48) | 2 (25) | 2 (9) | n/a |
HCM (%) | 3 (8) | 0 (0) | 4 (18) | n/a |
ICM (%) | 10 (25) | 1 (13) | 4 (18) | n/a |
Inflammatory (%) | 1 (2) | 2 (25) | 4 (18) | n/a |
Other (non-ICMP) (%) | 7 (17) | 3 (37) | 8 (36) | n/a |
CMR | ||||
LVEDVi (ml/m2 ± SD) | 136.1 ± 49.7 | 117.6 ± 18.6 | 87.4 ± 21.2 | 76.6 ± 11.0 |
LVESVi (ml/m2 ± SD) | 103.3 ± 47.4 | 69.8 ± 20.0 | 35.0 ± 11.3 | 29.3 ± 6.4 |
LVMi (g/m2 ± SD) | 76.0 ± 24.1 | 83.6 ± 23.3 | 62.3 ± 24.5 | 57.2 ± 8.9 |
LVCI (ml/min/m2 ± SD) | 2.5 ± 1.0 | 3.5 ± 1.1 | 3.9 ± 1.3 | 3.1 ± 0.7 |
LVEF (% ± SD) | 25 ± 8.7 | 43.3 ± 2.6 | 60.1 ± 8.1 | 61.6 ± 5.6 |
RVEDVi (ml/m2) | 86.5 ± 46.1a | 104.9 ± 11.2a | 85.8 ± 11.5a | 87.5 ± 15.5a |
RVESVi (ml/m2) | 63.9 ± 31.4a | 70.8 ± 33.3a | 49.8 ± 5.2a | 44.7 ± 12.6a |
RVCI (ml/min/m2 ± SD) | 1.9 ± 1.0 | 2.1 ± 0.8 | 2.6 ± 1.0 | 2.8 ± 0.7 |
RVEF (%) | 26.5 ± 11.7a | 32.1 ± 10.1a | 42.3 ± 8.1a | 49.3 ± 8.4 |
Native T1 (ms ± SD) | 1290 ± 57a | 1300 ± 55 | 1256 ± 82 | 1188 ± 46 |
ECV (% ± SD) | 31.5 ± 6.3 | 32.6 ± 10.1 | 27.7 ± 5.0 | 24.3 ± 2.2 |
Scar burden (% ± SD) | 6.5 ± 6.5 | 5.9 ± 14.6a | 6.7 ± 6.6 | 0.0 ± 0.0 |
RV/LV T2 ratio (± SD) | 0.50 ± 0.11 | 0.50 ± 0.10 | 0.54 ± 0.14 | 0.74 ± 0.05 |