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Table 1.2 Symptomatic Patients Without Known CCD and With Prior Testing*

From: ACC/AHA/ASE/ASNC/ASPC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2023 Multimodality Appropriate Use Criteria for the Detection and Risk Assessment of Chronic Coronary Disease

Clinical Scenario Text

ECG Treadmill

Stress Nuclear MPI

Stress Echo

Stress CMR

CAC

CCTA

Cath

No Test

6.

Abnormal ECG

M (4)

A (8)

A (8)

A (8)

M (5)

A (8)

M (5)

M (4)

7.

Normal ET

 

M (6)

M (6)

M (6)

M (5)

M (6)

R (3)

M (5)

8.

Inconclusive ET

 

A (8)

A (8)

A (7)

M (5)

A (8)

M (5)

R (3)

9.

Abnormal ET

 

A (8)

A (8)

A (7)

M (4)

A (8)

A (8)

M (5)

10.

Normal stress imaging†

R (1)

R (2)

R (2)

R (2)

M (4)

A (7)

M (5)

M (6)

11.

Mild ischemia on stress imaging†

R (1)

R (3)

R (3)

R (3)

R (3)

A (7)

M (6)

M (5)

12.

Inconclusive stress imaging†

R (1)

M (5)

M (5)

M (5)

M (4)

A (8)

M (6)

R (3)

13.

Moderate to severe ischemia on stress imaging†

R (1)

R (1)

R (1)

R (1)

R (2)

A (7)

A (9)

M (4)

14.

CCTA with no CAD or up to 49% stenosis (CAD-RADS 0–2)

M (4)

M (5)

M (5)

M (5)

R (1)

 

R (2)

M (6)

15.

CCTA with moderate stenosis 50%-69% (CAD-RADS 3)

M (6)

A (7)

A (7)

A (7)

R (1)

 

A (7)

M (5)

16.

CCTA with severe stenosis ≥ 70% (CAD-RADS 4–5)

M (5)

M (6)

M (6)

M (6)

R (1)

 

A (8)

M (5)

17.

CCTA inconclusive (CAD-RADS N)

A (7)

A (8)

A (8)

A (8)

R (1)

 

A (7)

R (3)

18.

CAC score = 0 (CAC-DRS 0)

M (5)

M (6)

M (6)

M (6)

 

M (5)

R (1)

M (5)

19.

CAC score 1–99 (CAC-DRS 1)

M (6)

M (5)

M (6)

M (5)

 

M (5)

R (3)

M (5)

20.

CAC score 100–299 (CAC-DRS 2)

A (7)

A (7)

A (7)

A (7)

 

A (7)

M (5)

M (4)

21.

CAC score ≥ 300 (CAC-DRS 3)

A (7)

A (7)

A (7)

A (7)

 

M (6)

M (6)

R (3)

22.

Invasive coronary angiography with mild or no CAD and/or normal invasive physiological testing‡

R (2)

M (3)

R (2)

M (4)

R (1)

R (1)

 

A (7)

23.

Invasive coronary angiography with intermediate severity and/or invasive physiological testing not done‡

M (5)

A (7)

A (8)

A (7)

R (1)

R (1)

 

M (4)

24.

Invasive coronary angiography with obstructive CAD and/or abnormal invasive physiological testing‡

R (2)

M (4)

M (4)

M (4)

R (1)

R (1)

 

M (4)

  1. If grayed out, rating not applicable
  2. A = Appropriate; ASCVD = atherosclerotic cardiovascular disease; CAC = coronary artery calcium score; CAC-DRS = Coronary Artery Calcium Data and Reporting System; CAD = coronary artery disease; CAD-RADS = Coronary Artery Disease-Reporting and Data System; cath = cardiac catheterization; CCD = chronic coronary disease; CCTA = coronary computed tomography angiography; CMR = cardiac magnetic resonance; CTCA = computed tomography coronary angiography; ECG = electrocardiogram; echo = echocardiography; ET = exercise stress test; M = May Be Appropriate; MPI = myocardial perfusion imaging; PET = positron emission tomography; R = Rarely Appropriate; SPECT = single-photon emission tomography
  3. ∗Refers to sequential testing being done as part of a continued patient evaluation or application of recent testing results in the reevaluation of a patient
  4. †Stress imaging could be SPECT, PET, echo, or CMR
  5. ‡Refers to diagnostic angiography, not percutaneous coronary intervention