Fig. 1
Experimental workflow and protocol. A Eight minipigs underwent either 15-min oversized balloon angioplasty (BA, n = 4) or oversized balloon angioplasty with additional endothelial denudation (BA + ECDN, n = 4) of the right carotid artery. B Vascular response to treatment was assessed by angiography at day zero. Perfluorooctyl bromide-nanoemulsion (PFOB-NE) was administered 3 days after injury. Vessel patency, analysis of the vascular wall and vessel blood flow was assessed by angiography and intravascular ultrasound (IVUS) at day 6. Afterwards, pigs were examined for vascular inflammation using in vivo and ex vivo 1H/19F MRI at 3.0 T and ex vivo high resolution 1H/19F MRI at 9.4 T followed by histology. BA = Balloon Angioplasty; ECDN = Endothelial Denudation; PFOB-NE, perfluorooctyl bromide-nanoemulsion