Fig. 4

BA + ECDN induces a robust ¹⁹F signal in vivo. Pigs (n = 8) were assessed for vascular ¹⁹F signal 6 days after graded vessel injury. Angiographic images with indicated angioplasty regions of interest. Note vascular stenosis (#) in the images of BA + ECDN. For anatomical in vivo co-localization ¹⁹F images were fused with ¹H 3D-T1 weighted images. ¹⁹F signal intensity is shown on a ‘hot iron’ color scale. After BA + ECDN, a robust ¹⁹F signal was detected in all pigs (right panels, n = 4) in vivo. No in vivo ¹⁹F signal was found in pigs following BA alone (left panels, n = 4). BA = Balloon Angioplasty; ECDN = Endothelial Denudation; SNR = Signal-to-noise ratio