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Table 2 Clinical and demographic associations with the presence of LGE on initial CMR

From: Late-gadolinium enhancement is common in older pediatric heart transplant recipients and is associated with lower ejection fraction

 

Na

All patients

LGE + 

LGE –

p-value

Demographics and graft characteristics

     

 Age, y, mean ± SD

59

14.1 ± 4.5

16.7 ± 2.9

12.8 ± 4.6

0.001

 Female sex, n (%)

59

33 (56%)

8 (42%)

25 (63%)

0.14

 Ischemic time, min, mean ± SD

51

209 ± 59

198 ± 49

213 ± 62

0.446

 Donor age at transplant, y, mean ± SD

53

9.9 ± 7.6

12.0 ± 7.3

9.0 ± 7.7

0.222

 Time since transplantation, y, mean ± SD

59

6.5 ± 4.7

8.3 ± 5.4

5.7 ± 3.9

0.041

Indication for transplant

     

 Cardiomyopathy, n (%)

59

21 (36%)

11 (58%)

10 (25%)

0.027

 Congenital heart disease, n (%)

33 (56%)

8 (42%)

25 (63%)

 Re-transplantation, n (%)

5 (8%)

0 (0%)

5 (13%)

Transplant comorbidities

     

 History of moderate or severe AMR or ACR, n (%)

58

16 (28%)

7 (39%)

9 (23%)

0.196

 PRA > 10% at transplant, n (%)

37

17 (46%)

2 (22%)

15 (54%)

0.101

 Hypertension diagnosis, n (%)

59

17 (29%)

7 (37%)

10 (25%)

0.881

 Clinical concern present, n (%)

59

17 (29%)

9 (47%)

8 (20%)

0.030

 History of any CAV, n (%)

59

6 (10%)

3 (16%)

3 (8%)

0.325

Cath/biopsy data

     

 Right atrial pressure, mmHg, mean ± SD

47

6.0 ± 4.3

6.3 ± 5.3

5.8 ± 3.6

0.709

 PCWP, mmHg, mean ± SD

48

12.0 ± 5.8

13.6 ± 8.3

11.2 ± 3.8

0.177

 Any rejection at time of cath, n (%)

48

13 (27%)

5 (29%)

8 (25%)

0.788

Global cardiac volumes and function (indexed)

     

 LVEDVI, ml/m2, mean ± SD

59

75 ± 14

78 ± 15

73 ± 13

0.190

 LVESVI, ml/m2, mean ± SD

59

31 ± 9

35 ± 12

29 ± 6

0.011

 LV EF, %, mean ± SD

59

59 ± 7

56 ± 8

61 ± 5

0.015

 LVMI, g, mean ± SD

55

46 ± 9

48 ± 11

45 ± 8

0.208

 RVEDVI, ml/m2, mean ± SD

58

74 ± 15

73 ± 14

74 ± 16

0.754

 RVESVI, ml/m2, mean ± SD

58

33 ± 11

33 ± 11

33 ± 11

0.924

 RV EF, %, mean ± SD

58

57 ± 8

56 ± 8

57 ± 8

0.689

  1. Bold values denote statistical significance
  2. ACR acute cellular rejection, AMR antibody mediated rejection, CAV cardiac allograft vasculopathy, LVEDVI left ventricular end-diastolic volume index, LVESVI left ventricular end-systolic volume index, LV EF left ventricular ejection fraction, PCWP pulmonary capillary wedge pressure, RVEDVI right ventricular end-diastolic volume index, RVESVI right ventricular end-systolic volume index, RV EF right ventricular ejection fraction, SD standard deviation
  3. aSome data were not available for patients undergoing initial CMR, n = 59. Variation in total “n” is based on available data
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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