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Table 2 Mean change of advanced CMR parameters during study period

From: Effect of etelcalcetide versus alfacalcidol on left ventricular function and feature-tracking cardiac magnetic resonance imaging in hemodialysis—a post-hoc analysis of a randomized, controlled trial

Mean change in CMR parameter at follow-up CMR

 

Total

Alfa

Etl

p-value for treatment effect *

 

N = 48

N = 23

N = 25

 

LVEF

0.2 (7.8)

− 0.4 (9.5)

0.8 (6.0)

0.513

LV CI

0.19 (0.82)

0.27 (0.98)

0.11 (0.65)

0.998

LV GLS

1.4 (4.3)

2.6 (4.6)

0.3 (3.8)

0.045

LV GCS

0.6 (8.1)

0.4 (9.1)

0.8 (7.3)

0.367

LV GRS

− 0.4 (5.7)

− 0.1 (5.7)

− 0.8 (5.7)

0.381

RV GLS

1.0 (6.1)

0.8 (6.4)

1.1 (5.9)

0.982

LA EF

− 2.4 (9.7)

− 1.6 (8.6)

− 3.0 (10.6)

0.684

LA GLS

− 4.2 (9.4)

− 4.5 (10.9)

− 4.0 (7.9)

0.390

T1 time (ms)

12 (46)

15 (42)

10 (50)

0.411

T2 time (ms)

− 0.42 (2.43)

− 0.13(2.45)

− 0.70 (2.43)

0.652

  1. Change of cardiovascular magnetic resonance imaging (CMR) parameters are displayed as mean (SD) difference from baseline CMR to follow-up CMR. Per-protocol dataset excluding patients with insufficient image quality
  2. CI cardiac index; EDV end-diastolic volume; EF ejection fraction; GCS global circumferential strain; GLS global longitudinal strain; GRS global radial strain; LA left atrial; LV left ventricle
  3. *p-value from repeated measure ANCOVA adjusting for baseline CMR parameter, study site, and residual renal function