Figure 1

(a) Mid-ventricular end-diastolic (top row) and end-systolic (bottom row) frames in the short-axis orientation of a male wild type mouse heart for the four different time points covering the study duration of one year. (b) Corresponding mid-ventricular end-diastolic (top row) and end-systolic (bottom row) frames in the short-axis orientation of a male GAMT-ko mouse heart at the respective time points. While the hearts of the transgenic mice were significantly smaller, cardiac function did not deteriorate over time, despite the lack of creatine. Scale bars: 2 mm.