Table 1 In ICM patients with severely reduced LVEF, women have worse outcomes, compared to men, despite similar risk factors, LVEF, myocardial scar burden and smaller volumes.
Total n = 349 | Men (n = 265) | Women (n = 84) | p-value |
|---|---|---|---|
Age (years) | 66 ± 11 | 64 ± 12 | 0.20 |
Diabetes Mellitus (%) | 75 (28) | 24 (29) | 0.9 |
Hypertension (%) | 93 (35) | 34 (40) | 0.4 |
Betablockers (%) | 150 (57) | 51 (60) | 0.6 |
Angiotensin converting enzyme inhibitors(%) | 126 (48) | 37 (44) | 0.6 |
Statins (%) | 142 (54) | 47 (56) | 0.70 |
History of coronary artery bypass grafting | 22 (8) | 7 (8) | 0.9 |
LV ejection fraction (%) | 23 ± 8 | 25 ± 8 | 0.23 |
LV enddiastolic volume (ml) | 241 ± 107 | 189 ± 88 | <0.001 |
LV endsystolic volume (ml) | 142 ± 90 | 100 ± 68 | 0.001 |
Mean scar % on DHE-MRI | 32 ± 21 | 29 ± 21 | 0.39 |
Number of segments with transmurality score ≥ 3 on DHE-MRI | 8.2 ± 5 | 7.7 ± 5 | 0.36 |
Global LV scar burden on DHE-MRI | 2.10 ± 1.1 | 2.00 ± 1.1 | 0.37 |
Post MRI revascularization (%) | 72 (27) | 17 (20) | 0.20 |
Post-MRI ICD or CRT | 70 (26) | 25 (30) | 0.55 |
Combined events (death or cardiac transplantation during follow-up) (%)* | 31 (12%) death and 5 cardiac transplantations | 20 (24) | 0.03 |