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Figure 1 | Journal of Cardiovascular Magnetic Resonance

Figure 1

From: 211 MRI of coronary vessel wall injury in a swine model of coronary intervention using an eletrostatically stabilized VSOP nanoparticle

Figure 1

We demonstrate the combined use of a matrix specific Gd-based contrast agent (BMS753951) together with an iron oxide nanoparticle for exclusive visualization of the pathologically altered coronary vessel wall. (A) Coronary angiogram of stented and balloon injured left coronary artery. Note that there are no artifacts from the bare metal stent. (B) T1 weighted inversion recovery delayed enhancement coronary vessel wall scan post BMS753951 injection demonstrating extracellular matrix formation one week post stent placement and injury. (C) Coronary MRA post VSOP injection demonstrating a strong T1 effect of the large vessels but an attenuated blood signal in the LAD suggestive for VSOP accumulation in the injured vessel wall (increased T2* effect of bound VSOP). (D) Delayed enhancement coronary vessel wall scan post BMS753951 and VSOP injection demonstrating displacement of the BMS753951 signal in the LAD due to VSOP accumulation in the injured vessel wall.

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