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Table 3 Mean estimated† change in LIC mg/gdw (Δ LIC) according to severity of hepatic siderosis between first two MR scans (minimum interval 12 months).

From: The efficacy of iron chelator regimes in reducing cardiac and hepatic iron in patients with thalassaemia major: a clinical observational study

  

Overall

Stratified

     

Heavy

Moderate

Mild

Regime

Time* (years)

n

Δ LIC

p

n

Δ LIC

p

n

Δ LIC

p

n

Δ LIC

p

DFO

2.0

36

+1.34

0.095

5

+2.31

0.68

11

+1.64

0.21

20

+0.94

0.27

DFP

1.9

14

-6.2

0.068

3

n.a.∂

n.a.

6

-0.97

0.3

5

+2.68

0.5

Comb

1.8

99

-4.19

<0.001

25

-9.18

0.003

45

-3.27

<0.001

29

-1.33

0.004

DFX

1.3

53

-2.80

0.005

21

-5.38

0.042

16

-2.08

0.042

16

-0.14

0.35

  1. *Time = mean time (in years) between MR scans.
  2. †Wilcoxon matched-pairs signed rank test
  3. ∂ Numbers too small for analysis