Magnetic resonance imaging of aortic regurgitation in Reversa mice. Left panel: Long-axis image of the left ventricle in early diastole before mitral valve opening. Arrow indicates turbulent dephasing of blood caused by diastolic flow across the aortic valve. Video images can be viewed in the on-line video supplement (Additional file 1). Right panel: prevalence of aortic regurgitation, graded by severity, in Reversa mice (n = 80) and in all normocholesterolemic control mice (n = 40). Tr-Mild = trace or mild. *p = 0.004, Reversa mice vs. control mice.