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Table 1 Animal Characteristics and Morphological Data.

From: Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging

 

2 month

7 month

10 month

control (n = 8)

mdx (n = 8)

control (n = 5)

mdx (n = 6)

control (n = 7)

mdx (n = 8)

Age, weeks

8.5 ± 1.3

9.2 ± 1.5

30.6 ± 1.8

33.7 ± 0.7

45.2 ± 2.8

43.5 ± 1.2

Body weight, g

26.9 ± 1.8

23.5 ± 4.1

32.2 ± 5.3

34.2 ± 1.0

30.0 ± 2.9

34.5 ± 2.0‡

Heart weight, mg

141 ± 20

127 ± 13

137 ± 6

158 ± 29

148 ± 12

170 ± 12‡

Heart weight/body weight, %

0.52 ± 0.05

0.55 ± 0.13

0.43 ± 0.06

0.46 ± 0.09

0.49 ± 0.03

0.49 ± 0.03

Heart rate, BPM

466 ± 42

441 ± 40

478 ± 38

481 ± 54

483 ± 29

500 ± 22

LV diameter, mm

5.37 ± 0.18

5.07 ± 0.35

5.43 ± 0.19

5.71+ 0.12

5.73 ± 0.25

5.75 ± 0.08

Wall thickness, mm

0.97 ± 0.16

0.81 ± 0.05

1.02 ± 0.08

1.04 ± 0.09

0.94 ± 0.04

1.04 ± 0.09*

Wall thickness/diameter

0.18 ± 0.03

0.16 ± 0.01

0.20 ± 0.03

0.18 ± 0.02

0.17 ± 0.01

0.19 ± 0.02

LVEDV, μl

42.8 ± 6.7

40.6 ± 7.4

42.1 ± 7.4

48.2 ± 6.7

51.0 ± 7.2

47.8 ± 4.2

LVESV, μl

15.3 ± 5.0

13.7 ± 3.5

18.6 ± 8.4

20.9 ± 5.3

24.0 ± 6.7

24.3 ± 2.9

Stroke volume, μl

27.5 ± 3.1

26.9 ± 4.3

25.9 ± 0.5

27.3 ± 2.3

27.0 ± 3.2

23.5 ± 3.1

Ejection fraction, %

65 ± 7

66 ± 4

63 ± 10

57 ± 5

54 ± 8

49 ± 5

Cardiac output, ml/min

12.9 ± 1.5

11.8 ± 1.6

12.7 ± 0.9

13.4 ± 1.3

13.0 ± 2.2

11.7 ± 1.4

  1. *P < 0.05, ‡P < 0.01 between mdx mice and age matched controls.