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Table 1 Animal Characteristics and Morphological Data.

From: Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging

  2 month 7 month 10 month
control (n = 8) mdx (n = 8) control (n = 5) mdx (n = 6) control (n = 7) mdx (n = 8)
Age, weeks 8.5 ± 1.3 9.2 ± 1.5 30.6 ± 1.8 33.7 ± 0.7 45.2 ± 2.8 43.5 ± 1.2
Body weight, g 26.9 ± 1.8 23.5 ± 4.1 32.2 ± 5.3 34.2 ± 1.0 30.0 ± 2.9 34.5 ± 2.0
Heart weight, mg 141 ± 20 127 ± 13 137 ± 6 158 ± 29 148 ± 12 170 ± 12
Heart weight/body weight, % 0.52 ± 0.05 0.55 ± 0.13 0.43 ± 0.06 0.46 ± 0.09 0.49 ± 0.03 0.49 ± 0.03
Heart rate, BPM 466 ± 42 441 ± 40 478 ± 38 481 ± 54 483 ± 29 500 ± 22
LV diameter, mm 5.37 ± 0.18 5.07 ± 0.35 5.43 ± 0.19 5.71+ 0.12 5.73 ± 0.25 5.75 ± 0.08
Wall thickness, mm 0.97 ± 0.16 0.81 ± 0.05 1.02 ± 0.08 1.04 ± 0.09 0.94 ± 0.04 1.04 ± 0.09*
Wall thickness/diameter 0.18 ± 0.03 0.16 ± 0.01 0.20 ± 0.03 0.18 ± 0.02 0.17 ± 0.01 0.19 ± 0.02
LVEDV, μl 42.8 ± 6.7 40.6 ± 7.4 42.1 ± 7.4 48.2 ± 6.7 51.0 ± 7.2 47.8 ± 4.2
LVESV, μl 15.3 ± 5.0 13.7 ± 3.5 18.6 ± 8.4 20.9 ± 5.3 24.0 ± 6.7 24.3 ± 2.9
Stroke volume, μl 27.5 ± 3.1 26.9 ± 4.3 25.9 ± 0.5 27.3 ± 2.3 27.0 ± 3.2 23.5 ± 3.1
Ejection fraction, % 65 ± 7 66 ± 4 63 ± 10 57 ± 5 54 ± 8 49 ± 5
Cardiac output, ml/min 12.9 ± 1.5 11.8 ± 1.6 12.7 ± 0.9 13.4 ± 1.3 13.0 ± 2.2 11.7 ± 1.4
  1. *P < 0.05, P < 0.01 between mdx mice and age matched controls.