Blood oxygen level-dependent MRI in patients with coronary artery disease and normal volunteers: a validation study against PET

Table 1 Rest MBF, stress MBF, coronary flow reserve (CFR) and BOLD-signal intensity (SI) change of stenosed, remote to ischemia and normal segments

	CAD patients		Normal volunteers
	STENOSED N = 59	REMOTE N = 73	NORMAL N = 60	P-value
REST MBF (ml/min/g)	0.95 ± 0.03 (0.90 – 1.01)	0.94 ± 0.03 (0.88 – 0.99) ^†	1.03 ± 0.03 (0.97 – 1.09)	0.04
REST MBF corrected [ml/min/g/(mmHg.bpm/10⁴)]	1.43 ± 0.05 (1.34 – 1.52)	1.42 ± 0.04 (1.34 – 1.51)	1.39 ± 0.04 (1.31 – 1.46)	0.76
HYPEREMIC MBF (ml/min/g)	2.11 (1.66 – 2.42) * ^‡	2.73 (2.16 – 3.44)^†	3.69 (3.16 – 4.61)	<0.001
CFR	2.31 (1.70 – 2.91) * ^‡	3.00 (2.31 – 3.98)	3.62 (2.89 – 4.93)	<0.001
CFR corrected	1.41 (1.06 – 2.00) * ^‡	2.01 (1.55 – 2.50)^†	2.68 (2.32 – 3.45)	<0.001
BOLD SI change (%)	1.25 (-2.38 – 7.89) * ^‡	8.91 (4.95 – 12.78)^†	14.08 (9.23 – 22.20)	<0.001

Data are presented as means ± standard deviation (95% confidence intervals) or median (interquartile range) as appropriate
Rest MBF corrected: rest MBF corrected for rate-pressure product (RPP), an index of myocardial oxygen consumption: MBF = (MBF/RPP) × 10⁴.
Stenosed: myocardial segments subtended by a >50% stenosed coronary artery.
Remote: myocardial segments subtended by arteries with minimal or no CAD.
Normal: myocardial segments in normal volunteers.
* p < 0.05 for comparison between stenosed and remote segments.
^† p < 0.05 for comparison between remote to ischemia and normal segments.
^‡ p < 0.05 for comparison between stenosed and normal segments.

ISSN: 1532-429X