Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation

Table 1 Physiological parameters at each experimental level

	BPsys (mmHg)	HR (min-1)	RPP (mmHg/min)	Flow (%)	SvO2 (%)
BL1	95.9 ± 2.2	72.0 ± 3.9	6865 ± 276	100.0 ± 0	0 ± 0
Ach1	95.6 ± 2.5	69.9 ± 3.2	6650 ± 258	127.7* ± 4.6	3.6 ± 2.3
Ach2	98.3 ± 1.7	67.3 ± 3.9	6598 ± 263	186.2* ± 13.3	5.3 ± 2.1
Ach3	99.1 ± 2.8	65.6 ± 3.5	6466 ± 282	309.7* ± 29.8	15. 7* ± 0.9
BL2	98.5 ± 3.0	67.2 ± 3.5	6577 ± 232	107.5 ± 5.2	5.2 ± 2.0
Ade1	97.7 ± 2.3	73.0 ± 3.2	7123 ± 304	817.9* ± 122.1	31.3* ± 2.6
Ade2	95.6 ± 4.1	73.4 ± 2.7	7018 ± 410	410.4* ± 64.7	28.9* ± 1.2
Ade3	99.0 ± 1.5	74.0 ± 8.7	7352 ± 981	532.2* ± 56.7	31.5* ± 0.6
BL3	94.6 ± 2.2	71.6 ± 2.3	6769 ± 259	117.2 ± 6.4	4.4 ± 1.4

p < 0.05 compared to baseline
Mean values and SEM for systolic blood pressure (sysBP), heart rate (HR), rate-pressure product (RPP), flow in the left circumflex coronary artery (flow) relative to baseline 1 and change in coronary sinus oxygen saturation (SvO₂) from baseline 1 at the different experimental levels (BL 1-3: baseline, ACh 1-3: intracoronary acetylcholine infusion/increasing doses, Ade 1-3: intracoronary adenosine infusion/increasing doses; detailed drug doses in the text). *: p < 0.05 vs. baseline (BL1).

ISSN: 1532-429X