Table 4 Diastolic Function and Pulmonary Arterial Pressure by Echocardiography Before and After Treatment
| Â | Baseline | Treatment | Before vs. After Treatment: Pair-wise Comparison (p value) | |||
|---|---|---|---|---|---|---|
| Â | Active | Sham | Active | Sham | Active | Sham |
E wave, cm/s | Â | Â | Â | Â | Â | Â |
   ≤ 1 cm/s | 90% (9/10) | 100%(10/10) | 90% (9/10) | 80% (8/10) |  |  |
   > 1 cm/s | 10% (1/10) | 0% (0/10) | 10% (1/10) | 20% (2/10) |  |  |
   p value | 1.0 | 1.0 | 1.0 | 0.25 | ||
E/A ratio | Â | Â | Â | Â | Â | Â |
   ≤ 0.75 | 40% (4/10) | 10% (1/10) | 0% (0/10) | 20%(2/10) |  |  |
   > 0.75 & < 1.5 | 30% (3/10) | 90%(9/10) | 90%(9/10) | 60%(6/10) |  |  |
   ≥1.5 | 30%(3/10) | 0%(0/0) | 10% (1/10) | 20%(2/10) |  |  |
   p value | 1.0 | 1.0 | 0.03 | 0.25 | ||
DT | Â | Â | Â | Â | Â | Â |
   < 140 ms | 0 (0/10) | 0 (0/10) | 0 (0/10) | 0 (0/10) |  |  |
   140-240 ms | 60% (6/10) | 80% (8/10) | 90% (9/10) | 70%(7/10) |  |  |
   > 240 ms | 40% (4/10) | 20% (2/10) | 10%(1/10) | 30%(3/10) |  |  |
   p value | 0.62 | 0.33 | 1.00 | 1.00 | ||
E' | Â | Â | Â | Â | Â | Â |
   ≤ 8 cm/s | 11% (1/9) | 20%(2/10) | 11% (1/9) | 40% (4/10) |  |  |
   > 8 cm/s | 89% (8/9) | 80%(8/10) | 89%(8/9) | 60%(6/10) |  |  |
   p value | 0.92 | 0.30 | 1.00 | 0.25 | ||
E/e' | Â | Â | Â | Â | Â | Â |
   < 8 | 66.7% (6/9) | 50% (5/10) | 44% (4/9) | 60% (6/10) |  |  |
   8-15 | 33.3%(3/9) | 50%(5/10) | 56%(5/9) | 40%(4/10) |  |  |
   > 15 | 0% (0/10) | 0% (0/10) | 0% (0/10) | 0% (0/10) |  |  |
   p value | 0.90 | 0.66 | 0.5 | 0.5 | ||
S/D ratio | Â | Â | Â | Â | Â | Â |
   S > D | 50%(4/8) | 40% (2/5) | 5/8 (50%) | 40% (2/5) |  |  |
   S = D | 50%(4/8) | 60% (3/5) | 3/8(30%) | 60% (3/5) |  |  |
   S < D | 0% (0/8) | 0 (0/5) | 0 (0/8) | 0 (0/5) |  |  |
   p value | 1.00 | 0.59 | 1.00 | 1.00 | ||