Figure 7
From: Quantitative cardiovascular magnetic resonance for molecular imaging
Quantitative 19F spectroscopy of angiogenesis in aortic valve disease. The 19F signal was utilized to quantify binding of nanoparticles to the valve leaflets from (A) a rabbit treated with ανβ3-targeted nanoparticles and (B) a rabbit treated with untargeted nanoparticles. Both nanoparticle formulations consisted of a crown ether core, which generates a single peak. The PFOB peaks originated from a reference standard utilized for quantification. Nanoparticle binding in the rabbit treated with targeted particles was much higher (Crown Ether/PFOB = 4.6) than the rabbit treated with nontargeted particles (Crown Ether/PFOB = 2.2). Reprinted with permission from Waters, et al [84].