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Figure 1 | Journal of Cardiovascular Magnetic Resonance

Figure 1

From: An isolated pig heart for the development, validation and translation of novel magnetic resonance techniques

Figure 1

A Scheme of the isolated perfusion mode. Starting from the perfusate resevoir (38°C) the perfusate is firstly passed through the roller pump 2 into a dialysis module and further through a blood oxygenator with integrated heat exchanger. The oxygenated blood is then pumped into the heart via roller pump 1. Before entering the heart an air trap removes air bubbles from the perfusate. The dialysate (38°C) is pumped through the dialysis module with a centrifugal pump (pump 3, flow of 51 min -1) to exchange metabolites between the venous perfusate and the dialysate. The dialysate is re-circulated in a resevoir. T: sensor for dialysate temperature: O2 and CO2: valves for oxygen and carbon dioxide input. The perfusate resevoir and the venous and arterial blood circiuts are fully water-jacketed. Termperature is controlled by an external heater. B Detail of the technical setup of the MR compatible perfusion system. All eletrical parts (control-unit, power-supply, pumps, etc) are placed approximately 6 meters distant to the magenet. The pump engines were then connected to the custom made MR compatible pump heads using polycarbon tubes. C Detail Heart Chamber

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