Figure 1

T1w images of various CION formulations. Cross-linking (top row) the outer lipid membrane dearly increases the T1 effects compared to without cross-linking (bottom row) as soes reducing the overall IO concentraion within the oily core of the CION (columns). At the highest iron concentration within the CION (45% w/v), the T2* effects overwhelm the T1 effects (bottom right).