Figure 1
T 2 * - weighted in vivo CCMR at 4.7 Tesla show monitored macrophages infiltration associated with CCAR progression on Post-operative days 14, 77, and 96 (A-C) respectively). The MPIO-labeled macrophage infiltration foci, appear as dark spots of hypointensity (arros) are confirmed with ex vivo high-resolution 3D MRM at 11.7 T (D, F), 3D rendering provides a whole-heart perspective of rejection and reaveals that macrophage infiltration during CCAR is heterogeneous. Fluorescence in microscopy confirms that thes dark spots are caused by MPIO-labeled macrophages (G, dragon green fluorescence).