Circumferential plaque distribution. A. T1 images showing circumferential heterogeneity in plaque thickness. Angular designation is shown in the first image, with the most medial point arbitrarily designated as 360 degrees. B-D. Regional plaque thickness on CMR at baseline and 6 months. Note significant regional variation in plaque thickness (+p < 0.05 versus 241-300 degrees at both 0 and 6 month periods, #p < 0.05 versus 301-360 degrees at both 0 and 6 month periods) with greater plaque thickness at 241-300 and 301-360 degree regions. In all subjects, significant change in plaque thickness was only seen in 61-120 degree region (B); in statin increase patients, significant change was seen in 61-120 and 301-360 degree regions (C). There was no significant regional change in thickness in statin maintain patients (D).