Clinical variables | Rosiglitazone therapy | Placebo therapy | Rosiglitazone therapy | Placebo therapy | Â | ||||
---|---|---|---|---|---|---|---|---|---|
 | Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | Δ baseline-follow-up | Δ baseline-follow-up | P-value |
Age (yrs) | 60 ± 6 | 61 ± 6 | < 0.001 | 57 ± 5 | 58 ± 5 | < 0.001 |  |  |  |
Body mass index (kg/m2) | 30.3 ± 4.5 | 28.7 ± 4.8 | 0.001 | 31.4 ± 4.9 | 29.2 ± 3.8 | 0.022 | -1.6 ± 1.0 | -2.2 ± 2.5 | 0.5 |
Waist circumference (cm) | 112 ± 11 | 104 ± 14 | 0.001 | 111 ± 12 | 102 ± 10 | 0.005 | -8 ± 5 | - 8 ± 7 | 0.9 |
Systolic blood pressure (mmHg) | 154 ± 23 | 136 ± 15 | 0.021 | 149 ± 14 | 135 ± 11 | 0.001 | -18 ± 21 | -14 ± 9 | 0.6 |
Diastolic blood pressure (mmHg) | 91 ± 11 | 78 ± 8 | 0.001 | 89 ± 6 | 78 ± 5 | < 0.001 | -13 ± 9 | -11 ± 5 | 0.6 |
Antihypertensive drugs, N (%) | 2 (20) | 4 (40) | 0.5 | 4 (40) | 4 (40) | 1.0 | Â | Â | Â |
Laboratory variables | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Triglycerides (mmol/l) | 1.8 ± 0.5 | 1.4 ± 0.3 | 0.008 | 1.9 ± 0.7 | 1.7 ± 0.6 | 0.3 | -0.4 ± 0.4 | -0.2 ± 0.5 | 0.3 |
HDL cholesterol (mmol/l) | 1.2 ± 0.2 | 1.4 ± 0.2 | 0.002 | 1.2 ± 0.2 | 1.2 ± 0.1†| 0.7 | 0.2 ± 0.2 | 0.02 ± 0.2 | 0.024 |
LDL cholesterol (mmol/l) | 3.8 ± 0.8 | 4.3 ± 0.6 | 0.079 | 3.9 ± 0.4 | 3.8 ± 0.5 | 0.7 | 0.6 ± 0.9 | -0.06 ± 0.4 | 0.063 |
Total cholesterol (mmol/l) | 5.8 ± 0.9 | 6.3 ± 0.7 | 0.1 | 5.9 ± 0.6 | 5.8 ± 0.6 | 0.5 | 0.6 ± 1.0 | -0.1 ± 0.6 | 0.075 |
Fasting blood glucose (mmol/l) | 5.0 ± 0.6 | 4.8 ± 0.7 | 0.098 | 5.7 ± 1.0 | 5.3 ± 1.1 | 0.071 | -0.3 ± 0.5 | -0.4 ± 0.6 | 0.6 |
HbA1c (%) | 5.2 ± 0.6 | 5.3 ± 0.4 | 0.3 | 5.2 ± 0.4 | 5.3 ± 0.3 | 1.0 | 0.1 ± 0.3 | 0.0 ± 0.4 | 0.5 |
Insulin (mmol/l)* | 11.5 (11.3) | 6.0 (4.3) | 0.034 | 11.5 (9.3) | 7.0 (5.8) | 0.007 | -4.2 ± 5.0 | -7.6 ± 7.3 | 0.3 |
HOMA-IR (mmol/l × mU/l)* | 1.5 (1.5) | 0.6 (0.5) | 0.021 | 1.6 (1.1) | 0.9 (0.8) | 0.007 | -0.6 ± 0.6 | -1.1 ± 1.0 | 0.2 |
hs-CRP (mmol/l)* | 2.4 (3.1) | 1.6 (1.7) | 0.047 | 2.6 (0.9) | 2.6 (2.6) | 0.6 | -1.7 ± 2.5 | 7.0 ± 21.2 | 0.2 |