Figure 5

Muti-contrast MR images (T1W, T2W DWI and MTC) of different stages of intraplaque hemorrhage (IPH) with histology (Trichrome and glyocophorin A) correlation. A, Fresh stage. IPH (arrows) is hyperintense on T1W, isointense on T2W, hyperintense on MTC, and hypointense on DWI corresponding with the red-staining intact erythrocytes on histology (Trichrome). B, Recent stage. IPH (arrows) is isointense on T1W, T2W, MTC and hyperintense on DWI. Trichrome shows dense fibrin network (red), and immunostaining for glycophorin A confirms the presence of erythrocytes (dark brown staining). C, Old stage. IPH (arrows) is shown isointense on T1W, hypointense on T2W and hypointense on MTC corresponding to the red-staining densely-packed amorphous material. Immunostaining for glycophorin A confirms the presence of erythrocytes (dark brown staining).