In vivo images acquired on an atherosclerosis patient using both MSDE (a) and iMSDE (b) techniques. Notice the dramatic signal difference on the fat region on both images (arrows). The signal intensity profiles along the dotted lines were plotted (c.d) for both images. Adter normalizing to the muscle signal, significantly higher fat signal was found in the MSDE case, compared to the iMSDE (arrow heads). Also notice the signal peak caused by the chemical shift from unsuppressed fat (open arrow).