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Table 4 Relationship between presence of late gadolinium enhancement (LGE) and clinical cardiac events in HCM

From: The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance

Study Number of patients % of study population with LGE Event Rate
Positive LGE versus Negative LGE groups
Hazard ratio (HR) or relative risk (RR) Primary endpoint
O'Hanlon et al. 2010 [73]. 217 63 24.5% LGE+ vs. 9.9% LGE- had primary endpoint HR 3.4 [1.4-8.1] Cardiovascular death, unplanned cardiovascular admission, sustained ventricular tachycardia or ventricular fibrillation, appropriate implantable cardioverter-defibrillator discharge
Rubinshtein et al. 2010[111]. 424 56 3.3% of LGE+ patients had SCD/ICD n/a Sudden cardiac death and appropriate implanted cardioverter defibrillator (ICD) discharge
Bruder et al. 2010 [118] 220 67.2 94% LGE+ vs. 66% LGE- had primary endpoint HR 8.0 [1.0-61.9] Sudden cardiac death and appropriate implanted cardioverter defibrillator (ICD) discharge.
Adabag et al. 2008 [70] 177 40.6 28% LGE+ vs. 4% LGE- w/NSVT RR 7.3 [2.6-20.4] Nonsustained ventricular tachycardia (NSVT) by Holter monitor
Paya et al. 2008 [113] 120 69 38% LGE+ vs. 8% LGE- had NSVT (p < 0.05) not indicated Nonsustained ventricular tachycardia (NSVT) by Holter monitor
Suk et al. 2008 [119] 25 64 88% LGE+ vs. 53% LGE- had VT (p < 0.05) not indicated Ventricular tachycardia by Holter or resting ECG
  1. HF: Heart failure
  2. ICD: intra-cardiac defibrillator.
  3. NSVT: Non-sustained ventricular tachycardia
  4. OR: Odds ratio.
  5. PVCs: Premature ventricular contractions
  6. VT: Ventricular tachycardia