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Table 4 Relationship between presence of late gadolinium enhancement (LGE) and clinical cardiac events in HCM

From: The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance

Study

Number of patients

% of study population with LGE

Event Rate

Positive LGE versus Negative LGE groups

Hazard ratio (HR) or relative risk (RR)

Primary endpoint

O'Hanlon et al. 2010 [73].

217

63

24.5% LGE+ vs. 9.9% LGE- had primary endpoint

HR 3.4 [1.4-8.1]

Cardiovascular death, unplanned cardiovascular admission, sustained ventricular tachycardia or ventricular fibrillation, appropriate implantable cardioverter-defibrillator discharge

Rubinshtein et al. 2010[111].

424

56

3.3% of LGE+ patients had SCD/ICD

n/a

Sudden cardiac death and appropriate implanted cardioverter defibrillator (ICD) discharge

Bruder et al. 2010 [118]

220

67.2

94% LGE+ vs. 66% LGE- had primary endpoint

HR 8.0 [1.0-61.9]

Sudden cardiac death and appropriate implanted cardioverter defibrillator (ICD) discharge.

Adabag et al. 2008 [70]

177

40.6

28% LGE+ vs. 4% LGE- w/NSVT

RR 7.3 [2.6-20.4]

Nonsustained ventricular tachycardia (NSVT) by Holter monitor

Paya et al. 2008 [113]

120

69

38% LGE+ vs. 8% LGE- had NSVT (p < 0.05)

not indicated

Nonsustained ventricular tachycardia (NSVT) by Holter monitor

Suk et al. 2008 [119]

25

64

88% LGE+ vs. 53% LGE- had VT (p < 0.05)

not indicated

Ventricular tachycardia by Holter or resting ECG

  1. HF: Heart failure
  2. ICD: intra-cardiac defibrillator.
  3. NSVT: Non-sustained ventricular tachycardia
  4. OR: Odds ratio.
  5. PVCs: Premature ventricular contractions
  6. VT: Ventricular tachycardia