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Table 2 Unadjusted hazard ratios for death or new heart failure

From: Late gadolinium enhancement by cardiovascular magnetic resonance is complementary to left ventricle ejection fraction in predicting prognosis of patients with stable coronary artery disease

  Unadjusted HR 95% Confidence Interval P value
ANTHROPOMETRIC
 Age (75 y) 1.70 0.92 – 3.17 0.093
 Male sex 0.92 0.67 – 1.27 0.614
 Body mass index >30 1.04 0.49 – 2.20 0.916
RISK FACTORS
 Familiar history of CAD 1.16 0.68 – 1.96 0.588
 Smoking habit 2.22 1.23 – 4.00 0.008
 Diabetes 0.88 0.45 – 1.70 0.698
 Hypertension 1.00 0.59 – 1.70 0.999
 Hypercholesterolemia 1.13 0.66 – 1.92 0.664
 # risk factors ≥ 3 1.58 0.93 – 2.69 0.093
CLINIC
 Previous CAD diagnosis 8.76 1.21 – 63.3 0.032
 Previous myocardial infarction 2.51 1.32 – 4.76 0.005
 NYHA classification ≥ 3 5.81 2.99 – 11.3 <0.0001
 Revascularization in the follow-up 0.36 0.15 – 0.85 0.019
THERAPY
 β-blockers 1.00 0.55 – 1.81 0.997
 Ca++−antagonist 1.15 0.63 – 2.12 0.644
 Nitrates 0.92 0.54 – 1.56 0.753
 Loop diuretics 5.26 2.94 – 9.40 <0.0001
 Aldosterone antagonist 5.69 3.29 – 9.86 <0.0001
 ACE-inhibitors/AT1-receptors antagonist 1.45 0.71 – 2.96 0.310
 ASA 0.69 0.36 – 1.30 0.251
 Statins 0.94 0.53 – 1.68 0.837
 Anticoagulant 6.38 3.49 – 11.7 <0.0001
ECG
 Heart rate (≥75 bpm) 2.80 1.62 – 4.84 <0.001
 Non sinusal rhythm 4.19 1.67 – 10.54 0.002
 QRS duration 2.62 1.47 – 4.70 0.001
 QTc interval 4.34 2.53 – 7.46 <0.0001
 LV hypertrophy 1.00 0.47 – 2.11 0.995
 LBB block 1.63 1.07 – 2.48 0.024
 RBB block 1.30 0.62 – 2.76 0.489
 ST segment depression 1.60 0.73 – 3.54 0.245
 Negative T waves 1.76 1.03 – 3.00 0.039
 Q waves 1.55 0.92 – 2.62 0.102
ECHOCARDIOGRAPHY
 LV EDV (≥ 105 ml/m2) 4.66 2.34 – 9.29 <0.0001
 LV ESV (≥ 75 ml/m2) 8.95 4.55 – 17.60 <0.0001
 LV EF (≤ 30%) 12.34 6.80 – 22.38 <0.0001
 LV WMSI (≥ 2.32) 10.94 5.53 – 21.62 <0.0001
 LV mass (≥ 310 g) 4.89 2.05 – 11.70 <0.001
 LV diastolic function (≥ pseudo-normal)† 7.03 4.00 – 12.38 <0.0001
 Mitral regurgitation (≥ moderate)‡ 4.67 2.68 – 8.13 <0.0001
 Pulmonary hypertension 4.86 2.68 – 8.80 <0.0001
 RVIT dilatation 1.45 0.92 – 2.30 0.112
 RV dysfunction 5.17 2.48 – 10.80 <0.0001
CMR
 LGE total burden ≥ 45% § 13.61 7.32 – 25.31 <0.0001
 LGE total burden ≥ 20% # 6.62 3.86 – 11.38 <0.0001
 LGE spatial Extent ≥ 68% § 9.27 4.86 – 17.66 <0.0001
 LGE spatial Extent ≥16% # 4.96 2.60 – 9.45 <0.0001
 LGE transmurality 4.82 2.81 – 8.31 <0.0001
  1. LV = left ventricle; LVEF = left ventricle ejection fraction; LBB = left bundle branch; RBB = right bundle branch; MR = mitral regurgitation; RVIT = right ventricle inflow tract; LGE = late gadolinium enhancement.
  2. † based on trans-mitral diastolic flow and pulmonary vein flow evaluation.
  3. ‡ based on effective regurgitate orifice area.
  4. § cut-off equal to the 95% percentile of the entire population.
  5. # cut-off equal to the 75% percentile of the entire population.