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Table 5 Sensitivity, Specificity, Positive and Negative Predictive Values and area under the receiver operating characteristic curve (AUC) of CMR Indices for the Detection of PH

From: Diagnostic accuracy of cardiovascular magnetic resonance imaging of right ventricular morphology and function in the assessment of suspected pulmonary hypertension results from the ASPIRE registry

 

Sensitivity

Specificity

PPV

NPV

AUC

Cardiac morphology

RVEDV index ≥ 75 ml/m2

67

50

89

20

0.72*

RV mass index ≥ 20 g/m2

83

84

96

50

0.91*

VMI ≥ 0.4

81

88

97

50

0.91*

Late gadolinium enhancement

83

94

98

58

0.89*

Right heart functional indices

RVEF ≤ 35%

67

71

93

28

0.72*

RVSVI ≤ 30 ml/m2

70

47

89

21

0.68*

TAPSE ≤ 2 cm

76

64

92

32

0.75*

f-TAAD ≤ 25%

88

56

92

44

0.78*

SFD ≤ 1 cm

77

67

93

34

0.73*

f-SFD ≤ 25%

79

64

92

35

0.78*

RVRAC ≤ 30%

61

81

95

28

0.79*

sEI ≥ 1.2

65

61

90

24

0.72*

dEI ≥ 1.17

62

54

88

20

0.57

Phase contrast CMR

Average velocity ≤ 10 (cm/s)

82

62

94

32

0.80*

Retrograde flow ≥ 0.3 (L/min/m2)

83

71

95

38

0.84*

Retrograde flow (%)

73

56

87

34

0.75*

PA relative area change ≥ 15%

86

70

94

48

0.87*

Systolic PA area ≥ 8 cm2

74

67

92

32

0.77*

Diastolic PA area ≥ 6 cm2

88

66

94

52

0.82*

  1. AUC (area under the curve) *p < 0.05.