Figure 16
From: Cardiovascular magnetic resonance physics for clinicians: part II
Non-linearity effects cause errors in MBF. The left hand graph shows the difference between the assumed linear relationship between signal intensity and Gd concentration (dotted line) and the true relationship (solid line). The right hand graph shows how the non-linear relationship at higher concentrations can propagate into a peak height error in the measured blood pool curve (the arterial input function or AIF) causing an overestimate in MBF.