A shows the signal intensity curves following gadolinium bolus administration in infarct regions which become hyperenhanced compared to the persistent hypoenhancement within the infarct core. Historically, hypoenhancement was measured at ~1 min (black arrow) following contrast administration. Reprinted from Judd, RM et al. Circulation 1995;92:1902–10. B shows the correlation between MO detected by thioflavin-S (left panel) compared to CMR (right panel). Reprinted from Rochitte C E et al. Circulation 1998;98:1006–1014.