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Table 1 Clinical studies of CMR MO

From: CMR of microvascular obstruction and hemorrhage in myocardial infarction

Study Method of MO assessment Imaging time post-MI Prevalence of MO Findings
Positive studies
Wu et al.[43] N = 44 · Early (yes/no) 10 days 25% MO predicted MACE at 16 mos. independently of infarct size
Hombach et al.[20] N = 110 · LGE (yes/no) 6 days 46% Late MO predicted MACE at 7.5 mos., independently of LVEF, LVEDV, infarct size
Bruder et al.[44] N = 67 · EGE 5 days 61% EGE MO > 0.5% predicted 1-yr MACE independently of LVEF & infarct size
Cochet et al.[45] N = 184 · First-pass LGE 3-7 days 69% (FP) Late MO predicted 1-yr MACE independently of LVEF & infarct size
47% (LGE)
De Waha et al.[46] N = 408 · EGE LGE 3 days 81% (FP) Late MO (presence/amount) better predicted MACE at 19 mos. with incremental value over LVEF & infarct size
73% (LGE)
Negative studies
Bodi et al.[47] N = 214 · LGE (yes/no) 7 days 31% Infarct transmural extent & wall motion score independently predicted MACE at 1.5 years.
Larose et al.[48] N = 103 · First-pass <12 h Not reported Infarct size was the strongest predictor of 6 mo. LVEF & 2-yr MACE
   6 months