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Figure 7 | Journal of Cardiovascular Magnetic Resonance

Figure 7

From: Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation

Figure 7

Phase contrast microscopy of myofiber architecture . Comparison of histological sections at 6 transmural depths in the lateral wall (1-6, from endocardium to epicardium) of a normal sheep heart (A) and the remote zone (B) of an infarcted sheep heart confirms a rightward shift of fibers in the remote zone. (C) Transmural gradient in HA calculated from the histological sections. The zero-crossing of the curve in the remote zone is significantly shifted towards the epicardium and thus the HA becomes more positive (normal vs. remote: * = p < 0.05). (D) Surface rendering of a normal heart depicting the location (green rectangle) of tissue blocks removed from the lateral LV wall for phase contrast microscopy. Sectioning was performed perpendicular to the normal of the epicardial surface of the tissue block. The coordinate system used to calculate fiber HA was identical to that shown for MR-tractography in Figure 1A. (E) Histological section at the subepicardial level and (F) corresponding ridges after Hessian-based analysis of local intensity structure.

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